Biochemistry of hypoglycin

Hypoglycin A: a specific inhibitor of isovaleryl CoA dehydrogenase.

Evidence is presented for the specific in vivo and in vitro inhibition of isovaleryl CoA dehydrogenation by hypoglycin A and its derivative, alpha-ketomethylenecyclopropylpropionic acid. alpha-Methylbutyryl CoA dehydrogenation was also impaired, but the degree of inhibition was much lower. Isobutyryl CoA dehydrogenation was not inhibited. 4-Pentenoic acid inhibited none of these reactions. It i...

The 15th Iranian National Congress of Biochemistry & 6th International Congress of Biochemistry and Molecular Biology

On the Mode of Action of Hypoglycin A

From evidence obtained by nuclear magnetic resonance, mass and infrared spectrometry, and chemical techniques, these compounds were identified as cis-4-decene-1, lodioic, cis,cis-4,7-decadiene-1, IO-dioic, cis-4-octene-1,8dioic, glutaric, and adipic acids, N-isovalerylglycine, and N-(methylenecyclopropyl)acetylglycine. (2 KE JOME JH YL ENE CYCLOPROP YL PROPIONiC CH =C8HCH 3 D COCOOH ACID / KMCP...

Editor Note – Biochemistry & Analytical Biochemistry

Biochemistry is the study of structures, functions and interactions of biomolecules, such as carbohydrates, nucleic acids, proteins, lipids, etc. and their metabolisms. Advancements in biochemistry helps in the advancement of different fields like agriculture, medicine, nutrition, etc., which are directly related to it. Combination of biochemical techniques with techniques and ideas of genetics...

Update on Biochemistry of Plant Volatiles Biochemistry of Plant Volatiles

Plants have a penchant for perfuming the atmosphere around them. Since antiquity it has been known that both floral and vegetative parts of many species emit substances with distinctive smells. The discovery of the gaseous hormone ethylene 70 years ago brought the realization that at least some of the compounds emitted may have physiological significance without any distinctive smell to humans....